Motif ID: RXR{A,B,G}.p2

Z-value: 1.926


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RXRAchr9_+_1363581450.582.3e-02Click!
RXRGchr1_-_163680941-0.175.4e-01Click!
RXRBchr6_-_332764160.117.0e-01Click!


Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_18081968 1.936 NM_002688
 SEPT5
septin 5
chr12_+_52105131 1.279 AMHR2
anti-Mullerian hormone receptor, type II
chr22_+_18085891 1.158 SEPT5
septin 5
chr22_+_18085990 1.132 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr1_-_38285033 1.048 NM_002699
 POU3F1
POU class 3 homeobox 1
chr12_+_56290229 0.975 NM_001111270
 ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr11_-_62136778 0.955 NM_153265
 EML3
echinoderm microtubule associated protein like 3
chr12_-_107775400 0.939 SSH1
slingshot homolog 1 (Drosophila)
chr17_+_78286687 0.906 NM_022158
 FN3K
fructosamine 3 kinase
chr6_-_167289659 0.866


chr11_-_75595098 0.829 NM_004626
 WNT11
wingless-type MMTV integration site family, member 11
chr21_-_32879617 0.829 NM_144659
 TCP10L
t-complex 10 (mouse)-like
chr19_-_54350457 0.819 NM_002152
 HRC
histidine rich calcium binding protein
chr16_-_69277355 0.787 NM_138383
 MTSS1L
metastasis suppressor 1-like
chr11_-_65187003 0.781 NM_001145138
NM_021975
 RELA

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

chr19_-_17349096 0.779 NM_031310
 PLVAP
plasmalemma vesicle associated protein
chr16_-_87244896 0.762 NM_000101
 CYBA
cytochrome b-245, alpha polypeptide
chr7_-_150283794 0.752 NM_172057
 KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr1_-_1840564 0.748 NM_178545
 TMEM52
transmembrane protein 52
chr15_-_73818013 0.721



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 61 entries
enrichment   p-value GO term description
2.18 2.27e-02 GO:0043254 regulation of protein complex assembly
1.94 1.01e-02 GO:0044087 regulation of cellular component biogenesis
1.75 4.92e-03 GO:0032535 regulation of cellular component size
1.68 3.86e-02 GO:0071495 cellular response to endogenous stimulus
1.68 4.23e-02 GO:0033043 regulation of organelle organization
1.63 1.70e-04 GO:0010629 negative regulation of gene expression
1.63 4.30e-02 GO:0090066 regulation of anatomical structure size
1.61 1.36e-03 GO:0051253 negative regulation of RNA metabolic process
1.61 1.65e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.58 1.04e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.58 2.33e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.57 2.05e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.56 7.64e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.56 1.25e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.55 3.95e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.53 1.44e-03 GO:0009890 negative regulation of biosynthetic process
1.48 2.45e-02 GO:0010628 positive regulation of gene expression
1.47 3.42e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.45 2.77e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.45 2.54e-02 GO:0010557 positive regulation of macromolecule biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
1.67 1.51e-02 GO:0015629 actin cytoskeleton
1.56 2.08e-02 GO:0043005 neuron projection
1.23 2.19e-02 GO:0005829 cytosol
1.12 1.04e-02 GO:0044444 cytoplasmic part
1.11 8.23e-05 GO:0005737 cytoplasm
1.09 5.94e-03 GO:0043231 intracellular membrane-bounded organelle
1.09 6.18e-03 GO:0043227 membrane-bounded organelle
1.08 2.30e-05 GO:0044424 intracellular part
1.08 6.29e-05 GO:0005622 intracellular
1.08 7.49e-03 GO:0043226 organelle
1.08 8.97e-03 GO:0043229 intracellular organelle
1.03 4.64e-02 GO:0044464 cell part
1.03 4.80e-02 GO:0005623 cell

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
1.68 7.19e-03 GO:0016563 transcription activator activity
1.54 1.72e-04 GO:0043565 sequence-specific DNA binding
1.46 4.13e-05 GO:0030528 transcription regulator activity
1.41 1.18e-03 GO:0001071 nucleic acid binding transcription factor activity
1.41 1.18e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.23 6.53e-03 GO:0003677 DNA binding
1.13 8.07e-05 GO:0005515 protein binding
1.06 6.39e-03 GO:0005488 binding